Vitamin B9 - Folinic Acid

Folacin is the generic term for folic acid and related substances having the biochemical activity of folic acid. Folate derivatives in the diet are cleaved by specific intestinal enzymes to monoglutanyl folate for absorption. Most of this is reduced to tetrahydrofolate in the intestinal wall by folate reductase. Tetrahydrofolate polyglutamates are the functional coenzymes in tissues. These are methenyl, methylene and methyl tetrahydrofolates and are all metabolically interconvertable. Folinic Acid (N5-Formyl-Tetrahydro Folate) is a stable form of folate readily converted to Methylene Tetra Folate and Methyl Tetrahydro Folate bypassing the methyltransferase conversion of Tetrahydro Folate to Methylene Tetrahydro Folate. Methyl Tetrahydro Folate is necessary in DNA synthesis during cell division. It also donates its methyl group to cobalamin (B12) to recycle homocysteine to methionine.

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